I have been running Drupal since about 2003, thanks to Boris. (Take that either direction you want BMann... ;)) And now that is is starting to "get popular and take over the world" - in quotes because I am sure Boris has said this at some point in the last few months - I am getting slammed by spambots.
I have about 13000 spam posts on my personal blog (it Googles quite highly) and less on this site. I used to use the Spam module when I was running Drupal 4.x but when I moved to 5.x that module was not ready for prime time so I skipped the installation.
Whoops.
Now, I have remediated this fact by putting the more capable (hopefully) Akismet spam module in place. Sure, it required me to get a WordPress.com user account (took all of 30 seconds - good work Lloyd & Co.) to get an API key to use this module but when I had the thing up for a grand total of a minute and the spam blocked count was already at 1, I know I had a winner.
If you run Drupal - use a spam guard of some sort. Or enjoy pressing Delete 260 times, as I will when I finally get around to removing the backlog. I guess I should file a feature request "Ability to purge an entire queue"...